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NDT Advance Access originally published online on November 8, 2005
Nephrology Dialysis Transplantation 2006 21(1):10-13; doi:10.1093/ndt/gfi250
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

Possible new perspectives for our understanding of nephrotic syndrome recurrence

Caroline Hervé1 and Jacques Dantal2

1 INSERM U643, ITERT and 2 Service de Néphrologie, Immunologie Clinique, 30 Bd Jean Monnet, CHU Nantes, 44093 Nantes, France

Correspondence and offprint requests to: Jacques Dantal, Service de néphrologie, immunologie clinique, 30 Bd Jean Monnet, 44093 Nantes Cedex, France. Email: jacques.dantal@chu-nantes.fr

Keywords: nephrotic syndrome; permeability factors; podocyte; recurrence

The first 150 words of the full text of this article appear below.



   Introduction
 
The identification and characterization of circulating factors that alter glomerular permeability in idiopathic nephrotic syndrome (INS) remain the subject of intensive research in nephrology. The existence of such factors was initially evoked by Shalhoub in 1974 [1] and, although they are thought to be of T-cell origin, their precise nature remains elusive. INS recurs immediately after kidney transplantation in 30% of patients with corticosteroid- or cyclosporin A-resistant INS [2]. The rapidity of this recurrence and the beneficial effects of plasmapheresis [2] and/or immunoadsorptions [3], together with several cases of materno-fetal transmission of glomerular abnormalities [4], lend credence to the involvement of plasmatic factors. In addition, the beneficial effects of corticosteroids and/or immunosuppressive therapies on the initial disease and the T-cell abnormalities recently reported in steroid-sensitive INS [5] indirectly support a T-cell origin.



   Hypothetical plasmatic factors
 
Major discrepancies have been revealed in . . . [Full Text of this Article]



   Genetic contribution
 


   Podocyte culture techniques
 


   The nephrotic stage: a critical balance
 


   Conclusion
 

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