Skip Navigation


NDT Advance Access originally published online on June 7, 2005
Nephrology Dialysis Transplantation 2005 20(8):1529-1532; doi:10.1093/ndt/gfh922
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/8/1529    most recent
gfh922v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Anders, H.-J.
Right arrow Articles by Patole, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anders, H.-J.
Right arrow Articles by Patole, P. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Editorial Comment

Toll-like receptors recognize uropathogenic Escherichia coli and trigger inflammation in the urinary tract

Hans-Joachim Anders and Prashant S. Patole

Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany

Correspondence and offprint requests to: Dr H.-J. Anders, Medizinische Poliklinik der LMU, Pettenkoferstr. 8a, D-80336 Munich, Germany. Email: hjanders@med.uni-muenchen.de

Keywords: chemokines; immunity; infection; leukocytes

The first 150 words of the full text of this article appear below.



   Introduction
 
Urinary tract infection (UTI) is one of the most common types of infection. In the USA, >US$1.6 billion per year are spent in the management of UTI [1]. Amongst the pathogens that can cause UTI, uropathogenic Escherichia coli (UPEC) has been found to be the causative organism in ~80% of cases. A number of pathogen-related virulence factors have been identified that relate mostly to pathogen adhesion to the epithelial lining of the urinary tract [2–4]. In addition, patient-related factors determine the prevalence and severity of UTI. Diabetes, immunosuppression, reflux and obstruction due to structural abnormalities of the urinary tract or pregnancy are known to predispose to UTI. These conditions affect either physiological urine flow or cellular immunity against uropathogenic agents. However, the patient-related risk for UTI may also be determined by pathogen recognition and pathogen-induced signalling for host defence. Host defence in UTI is based on . . . [Full Text of this Article]



   Toll-like receptors are innate pathogen recognition receptors
 


   TLR4 and TLR11 signal for renal neutrophil recruitment in mice with UTI
 


   Do intrinsic renal cells signal through TLRs during UPEC infection?
 


   Are data from mouse models relevant for human UTI?
 


   Future directions
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
A. L. Lloyd, S. N. Smith, K. A. Eaton, and H. L. T. Mobley
Uropathogenic Escherichia coli Suppresses the Host Inflammatory Response via Pathogenicity Island Genes sisA and sisB
Infect. Immun., December 1, 2009; 77(12): 5322 - 5333.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Bhushan, S. Tchatalbachev, J. Klug, M. Fijak, C. Pineau, T. Chakraborty, and A. Meinhardt
Uropathogenic Escherichia coli Block MyD88-Dependent and Activate MyD88-Independent Signaling Pathways in Rat Testicular Cells
J. Immunol., April 15, 2008; 180(8): 5537 - 5547.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. D. Saemann, W. H. Horl, and T. Weichhart
Uncovering host defences in the urinary tract: cathelicidin and beyond
Nephrol. Dial. Transplant., February 1, 2007; 22(2): 347 - 349.
[Full Text] [PDF]