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Nephrology Dialysis Transplantation 2005 20(7):1287-1290; doi:10.1093/ndt/gfh857
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

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Electrophysiology of the renin-producing juxtaglomerular cells

Ulla G. Friis, Boye L. Jensen, Finn Jørgensen, Ditte Andreasen and Ole Skøtt

Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark

Correspondence and offprint requests to: Dr Ulla G. Friis, Physiology and Pharmacology, University of Southern Denmark, Winsloewparken 21,3, DK-5000 Odense C, Denmark. Email: ufriis@health.sdu.dk

Keywords: BKCa; Cav; cAMP; cGMP; exocytosis

The first 10% of the full text of this article appears below.



   Introduction
 
Renin is an aspartyl-proteinase hormone that is produced, stored and released by juxtaglomerular (JG) granular cells in the distal part of the renal afferent arterioles. The rate of secretion of renin from JG cells is one of the main determinants of the overall activity of the renin-angiotensin system, and is the most well regulated parameter of all constituents of that system.

At least three cellular messengers are involved in the intracellular control of renin secretion. Intracellular calcium is an inhibitory second messenger and is increased after exposure of the JG cells to vasoconstrictors such as angiotensin II, a1-adrenergic agonists or endothelin [1]. Cyclic AMP stimulates the secretory process and is involved in the stimulation of renin secretion seen after exposure to vasodilator hormones coupled to activation of adenylyl cyclase (dopamine [2], b-adrenergic agonists [3], prostaglandin E2, prostaglandin I2 and adrenomedullin . . . [Full Text of this Article]



   Ion channels in single JG cells
 


   The cAMP pathway
 


   The PDE-3 pathway
 


   Conclusions
 

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