Skip Navigation


NDT Advance Access originally published online on October 14, 2005
Nephrology Dialysis Transplantation 2005 20(12):2620-2622; doi:10.1093/ndt/gfi192
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/12/2620    most recent
gfi192v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wicek, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wicek, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

How does leptin contribute to uraemic cachexia?

Andrzej Wicek

Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice Poland

Correspondence and offprint requests to: Prof. Andrzej Wicek FRCP (Edin.), Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Francuska 20/24 Str. 40-027 Katowice/Poland. Email: awiecek@spskm.katowice.pl

Keywords: leptin; malnutrition

The first 150 words of the full text of this article appear below.

Malnutrition (wasting or cachexia) is frequently observed in uraemic patients, both in the predialysis phase and during renal replacement therapy [1,2]. According to the DOPPS, every 4th to 5th dialysis patient suffers from moderate or severe malnutrition [3]. It was also found that dietary energy and protein intakes are inadequate in the majority of haemodialysis patients [4]. For many years, it has been known that wasting or cachexia is an important predictor of morbidity and mortality due to cardiovascular and infectious diseases among uraemic patients [5]. However, the pathophysiology of wasting in these patients is very complex and not entirely known [6]. Several factors contribute to protein–energy malnutrition in patients with end-stage renal disease (ESRD) including: metabolic acidosis, chronic inflammation, low protein diet, resistance to anabolic hormones and anorexia [7]. The discovery of leptin immediately stimulated . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. Bossola, S. Giungi, L. Tazza, and G. Luciani
Does desacyl ghrelin contribute to uraemic anorexia?
Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3673 - 3674.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Bossola, M. Muscaritoli, L. Tazza, F. R. Fanelli, and G. Luciani
Does leptin contribute to uraemic cachexia?
Nephrol. Dial. Transplant., April 1, 2006; 21(4): 1125 - 1126.
[Full Text] [PDF]