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NDT Advance Access originally published online on September 27, 2005
Nephrology Dialysis Transplantation 2005 20(11):2318-2320; doi:10.1093/ndt/gfi164
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Translational Nephrology

Tubular regeneration and the role of bone marrow cells: ‘stem cell therapy’ – a panacea?

Marc E. De Broe

Department of Nephrology, University of Antwerp, Belgium

Correspondence and offprint requests to: Marc E. De Broe, M.D., PhD, Department of Nephrology, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk (Antwerpen), Belgium. Email: marc.debroe@ua.ac.be

The first 10% of the full text of this article appears below.

The kidney possesses an impressive regeneration capacity and is the most performant among all tissues in the body. Yet ischaemic injury to the kidney produces acute tubular necrosis and apoptosis followed by tubular regeneration and recovery of renal function. Although mitotic cells are present in the tubules of postischaemic kidneys, the origins of the proliferating cells were considered until recently as the result of this regeneration capacity of the kidney, whereby the surviving remaining tubular cells start proliferating and migrating along the denuded basement membrane.

In both humans and mice, the proof-of-principle clinical observation has been obtained in support of the ability of cells emanating from the bone marrow (BM) to become renal epithelial cells. Several groups have reported the presence of Y-chromosome-positive renal tubular cells in kidneys of male recipients who received a renal transplant . . . [Full Text of this Article]


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