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NDT Advance Access originally published online on July 26, 2005
Nephrology Dialysis Transplantation 2005 20(11):2307-2310; doi:10.1093/ndt/gfi002
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org


Editorial Comment

Age, the riddle of renal transplantation

Johan W. de Fijter1 and Guido G. Persijn2

1 Department of Nephrology, Leiden University Medical Center and 2 Eurotransplant International, Leiden, The Netherlands

Correspondence and offprint requests to: Johan W. de Fijter, MD, PhD, Department of Nephrology, C3-P22, Leiden University Medical Center, PO Box 9600, NL-2300 RC Leiden, The Netherlands. Email: jwdefijter@lumc.nl

Keywords: age; immunosuppression; kidney; outcome; rejection; transplantation

The first 150 words of the full text of this article appear below.



   Introduction
 
In the Western world there is a progressive increase in the number of patients with end-stage renal failure, which is largely due to an increase in patients over 65 years of age. As successful renal transplantation improves both longevity and quality of life compared with long-term dialysis treatment [1], more elderly patients are placed on the transplant waiting list. In the United States Renal Data System, the percentage of recipients of 55 years or older increased between 1988 and 1998 from 17.5 to 32.2% [2]. Also in the Eurotransplant countries, there has been a significant increase in recipients ≥50 or ≥65 years between the periods 1985–1989 and 2000–2004 from 33.1 to 53.2% and from 1.5 to 17.7%, respectively (Figure 1).


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Fig. 1. Proportions of renal transplant recipients ≥50 or ≥65 years of age in recent years.

 
The magnitude of improved patient survival is not uniform across . . . [Full Text of this Article]



   Should kidneys from older donors be transplanted preferentially into old recipients?
 


   Conclusion
 

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