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NDT Advance Access originally published online on July 19, 2005
Nephrology Dialysis Transplantation 2005 20(11):2304-2307; doi:10.1093/ndt/gfh994
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial Comment

Zenon's paradox or how much to lower blood pressure for optimal renoprotection

Gunter Wolf

Klinik für Innere Medizin III, Friedrich-Schiller-University, Jena, Germany

Correspondence and offprint requests to: Prof. Gunter Wolf, Klinik für Innere Medizin III, University Hospital Jena, Erlanger Allee 101, D-07747 Jena, Germany. Email: gunter.wolf@med.uni-jena.de

Keywords: progression of renal disease; blood pressure; proteinuria; angiotensin II; ace inhibitor

The first 150 words of the full text of this article appear below.



   Introduction
 
The Greek philosopher Zenon, who lived almost 2500 years ago, came up with strange ideas. One is the famous race between Achilles, the fastest runner of Greek mythology, and an old tortoise [1]. Achilles, as a true hero, agreed to give the tortoise an advantage and the tortoise started 10 m in front of Achilles. For Achilles to get in front of the tortoise, he first had to run to the place where the tortoise started. But in that time the tortoise had covered some distance, which Achilles now had to run in order to catch up. However, in this time again the tortoise had gone some distance and Achilles was still behind the tortoise. This process continued forever and apparently Achilles could never pass the tortoise. Our everyday experience suggests that Achilles, even suffering acute problems with his heels, could easily pass the tortoise. Nevertheless, Zenon's arguments . . . [Full Text of this Article]



   The REIN-2 study
 


   Blood pressure control and nephroprotection
 


   ACE inhibitors and nephroprotection
 


   Proteinuria as a primary target?
 

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