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NDT Advance Access originally published online on August 16, 2005
Nephrology Dialysis Transplantation 2005 20(10):2028-2031; doi:10.1093/ndt/gfh963
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Editorial Comment

Steroid sparing strategies in renal transplantation

Josep M. Grinyó

Servei de Nefrologia, Hospital Universitari de Bellvitge, University of Barcelona, C. Feixa Llarga s/n, L'Hospitalet, 08907 Barcelona

Correspondence and offprint requests to: Josep M. Grinyó, Servei de Nefrologia, Hospital Universitari de Bellvitge, University of Barcelona, C. Feixa Llarga s/n, L'Hospitalet, 08907 Barcelona. Email: jgrinyo@csub.scs.es

Keywords: renal transplantation; steroid sparing

The first 150 words of the full text of this article appear below.



   Introduction
 
In the last few years, the aim in the majority of immunosuppressive regimens has been to reduce the incidence and severity of acute rejection, because acute rejection is considered a prognostic factor for poor graft outcome. In the last decade, many renal transplant centres have used triple therapy consisting of a calcineurin-inhibitor (CNI), an antimetabolite, and steroids as induction and maintenance regimens. In this period, nearly all kidney transplant recipients received corticosteroid therapy prior to discharge, although the proportion of patients receiving steroids declined slightly at the end of this period [1]. This trend may reflect concern in the transplant community about the importance of steroid-related morbidity in transplanted patients. As a consequence, different attempts have been made to spare steroids in order to reduce co-morbidity. However, steroid sparing strategies may increase the risk of acute and chronic rejection that in turn may jeopardize transplant outcome. In this . . . [Full Text of this Article]



   Steroid-sparing protocols in the CsA era
 


   Steroid-sparing regimens with new immunosuppressants
 

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