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NDT Advance Access originally published online on July 19, 2005
Nephrology Dialysis Transplantation 2005 20(10):2022-2024; doi:10.1093/ndt/gfh984
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Editorial Comment

Blood pressure salt sensitivity: a biomeasure of kidney disease susceptibility in diabetics?

Matthew R. Weir

Division of Nephrology, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA

Correspondence and offprint requests to: Matthew R. Weir, University of Maryland Hospital, Renal Division, Baltimore, MD 21201, USA. Email: mweir@medicine.umaryland.edu

The first 10% of the full text of this article appears below.



   Introduction
 
Is it this simple? Could it be that simply defining blood pressure responses to variations in dietary salt will identify those patients genetically, or possibly environmentally, predisposed to developing kidney disease? Is salt-sensitive blood pressure an intermediate phenotype linked to the genesis of diabetic kidney disease?



   The Strojek study
 
The interesting study of Strojek et al. [1] does not answer the question. What this study does suggest is that in a highly selected, small population of offspring of diabetics with chronic kidney disease (CKD), there are intriguing relationships of salt-induced changes in blood pressure and a higher mean urinary (THF + 5{alpha}THF)/THE ratio. Thus, there is biological plausibility to . . . [Full Text of this Article]



   Is a salt-induced change in microalbuminuria a better target for study?
 


   Conclusions
 

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Related articles in NDT:

Salt-sensitive blood pressure—an intermediate phenotype predisposing to diabetic nephropathy?
Krzysztof Strojek, Jerome Nicod, Paolo Ferrari, Wladyslaw Grzeszczak, Juta Gorska, Bernard Dick, Felix Frey, and Eberhard Ritz
NDT 2005 20: 2113-2119. [Abstract] [FREE Full Text]