NDT Advance Access originally published online on November 16, 2004
Nephrology Dialysis Transplantation 2005 20(1):6-10; doi:10.1093/ndt/gfh570
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Nephrol Dial Transplant Vol. 20 No. 1 © ERA-EDTA 2004; all rights reserved
Editorial Comment
Imbalance of growth factor signalling in diabetic kidney disease: is connective tissue growth factor (CTGF, CCN2) the perfect intervention point?
1 Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands and 2 Medical Research Laboratories, Medical Department M (Diabetes and Endocrinology), Aarhus University Hospital, Clinical Institute, DK-8000 Aarhus C, Denmark
Correspondence and offprint requests to: Frans A. van Nieuwenhoven, PhD, Department of Pathology, H04.312, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Email: f.a.vannieuwenhoven@azu.nl
Keywords: clinical marker; CTGF; diabetes; nephropathy; therapy
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Introduction |
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The prevalence of diabetes mellitus and its clinical complications are increasing rapidly worldwide. Diabetic nephropathy has already become the leading cause of end-stage renal disease in developed countries and is thus forming an increasing clinical problem [1]. Mesangial matrix accumulation and glomerular basement membrane (GBM) thickening are primary structural alterations characteristic for diabetic nephropathy [2]. These structural changes are accompanied by increased permeability of the GBM for proteins, resulting in increased urinary albumin excretion (UAE). Growth factors and cytokines such as transforming growth factor-ß (TGF-ß), growth hormone, insulin-like growth factor (IGF) and vascular endothelial growth factor (VEGF) play important roles in the development of diabetic nephropathy [2,3]. In addition to these ‘pro-fibrotic’ growth factors, the ‘anti-fibrotic’ growth factor bone morphogenetic protein-7 (BMP-7) has been reported to be downregulated in diabetic nephropathy, and addition of BMP-7 in experimental diabetes is capable of antagonizing
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Connective tissue growth factor (CTGF, CCN2) |
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CTGF as a clinical marker for the development of diabetic nephropathy |
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Pathogenic role of CTGF in diabetic nephropathy |
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CTGF as potential target for therapeutic intervention |
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Conclusions |
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