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Nephrology Dialysis Transplantation 2004 19(9):2166-2170; doi:10.1093/ndt/gfh376
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Nephrol Dial Transplant Vol. 19 No. 9 © ERA-EDTA 2004; all rights reserved

Editorial Comment

Fibrillary glomerulonephritis and immunotactoid glomerulopathy

Bela Ivanyi1 and Peter Degrell2

1 Department of Pathology, University of Szeged and 2 2nd Department of Medicine and Nephrological Center, University of Pécs, Hungary

Correspondence and offprint requests to: Dr Béla Iványi, Department of Pathology, University of Szeged, Állomás u. 2, H-6720 Szeged, Hungary. Email: ivanyi@patho.szote.u-szeged.hu

Keywords: amyloid; cryoglobulinaemia; fibrillary glomerulonephritis; immunotactoid glomerulopathy; lupus glomerulonephritis

The first 150 words of the full text of this article appear below.



   Introduction
 
Microfibrils or microtubules in the mesangium and the glomerular basement membrane may be observed ultrastructurally in a variety of renal disorders, commonly termed glomerulopathies (GPs) with organized deposits (synonym: glomerular fibrilloses). The microfibrils have no lumen, lack periodicity, are arranged randomly and may be derived from amyloid proteins, immunoglobulins or extracellular matrix proteins. The microtubules have a lumen, tend to be ordered in parallel bundles and are composed of immunoglobulins. The diagnostic algorithm of GPs with organized deposits is shown in Table 1. The pathogenesis and biochemistry of GPs with Congo red-negative organized immunoglobulin deposits have not yet been elucidated fully and their classification remains, therefore, somewhat controversial [1,2]. Some investigators distinguish fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG) on the basis of the substructure of the deposits (fibrillary vs microtubular) and include patients with associated systemic disease [3–6]. Others regard GPs with . . . [Full Text of this Article]



   Fibrillary glomerulonephritis
 


   Immunotactoid glomerulopathy
 


   Comment
 


   Summary
 

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