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Nephrol Dial Transplant (2004) 19: 1951-1955
Nephrol Dial Transplant Vol. 19 No. 8 © ERA-EDTA 2004; all rights reserved

Editorial Comment

Restoring glutathione as a therapeutic strategy in chronic kidney disease

Francesco Santangelo1, Véronique Witko-Sarsat2, Tilman Drüeke2 and Béatrice Descamps-Latscha2

1 Via Passo di Fargorida 5, Milano, Italy and 2 INSERM U507, Hôpital Necker, Paris, France

Correspondence and offprint requests to: Béatrice Descamps-Latscha, MD, PhD, INSERM U507, Hôpital Necker, 161 rue de Sèvres, 75015 Paris, France. Email: b.descamps@necker.fr

Keywords: chronic kidney disease; glutathione; oxidative stress; therapeutic strategy; thiol pool

The first 150 words of the full text of this article appear below.



   Glutathione: antioxidant and cell function regulator
 
The oxidation–reduction (redox) state of the pool of cellular thiols plays a central role in antioxidant defence and in the regulation of a large number of signal transduction pathways and metabolic functions [1]. The tripeptide glutathione (GSH), i.e. L-{gamma}-glutamyl-L-cysteinyl-glycine (MW 307), represents the major low-molecular-mass thiol compound participating in cellular redox reactions and thio-ether formation. Under oxidative stress, GSH is oxidized to glutathione disulphide (GSSG) and further to other products such as sulphonates. Glutathione-cysteinyl disulphides can also be formed on proteins and such bound glutathione makes up a considerable amount of the cellular glutathione pool.

In January 2004, nearly 60 000 entries could be found under the term ‘glutathione’ in the Medline database, reflecting the importance of this biomolecule. Current knowledge concerning the regulation of mammalian glutathione synthesis is given in Griffith [2]. Briefly, GSH is synthesized from L-glutamate, L-cysteine . . . [Full Text of this Article]



   Oxidative stress in chronic renal insufficiency
 


   Importance of the glutathione system in chronic renal insufficiency-associated oxidative stress
 


   Glutathione repletion in dialysis patients
 
Cysteine supply


   Restoring the thiol pool—a worthwhile therapeutic strategy?
 


   Conclusion
 

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