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Nephrol Dial Transplant (2004) 19: 770-773
Nephrol Dial Transplant Vol. 19 No. 4 © ERA-EDTA 2004; all rights reserved

Editorial Comment

Renin–angiotensin system and atherosclerosis

Karsten Grote, Helmut Drexler and Bernhard Schieffer

Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany

Correspondence and offprint requests to: Bernhard Schieffer, MD, Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. Email: Schieffer.Bernhard@MH-Hannover.de

Keywords: angiotensin II; AT1 receptor; atherosclerosis; inflammation; renin–angiotensin system

The first 150 words of the full text of this article appear below.



   Introduction
 
Cardiovascular (CV) events remain the main cause of morbidity and mortality in industrialized societies. Atherosclerosis is a chronic inflammatory disease [1] initiated and perpetuated by a variety of CV risk factors such as smoking, diabetes mellitus, hypertension and elevated plasma low-density lipoprotein (LDL) [2]. Atherosclerotic plaques are conglomerates composed of dysfunctional endothelial cells, smooth muscle cells, lipid-laden macrophages and T lymphocytes. These lipid-laden activated macrophages and T-lymphocytes stimulate their neighbouring cells to erode the collagen and elastin framework which forms the plaque's cap [1–5]. Myocardial infarction, stroke or sudden cardiac death are the fatal end-points of progressive atherosclerosis and are thought to be the result of these pathological remodelling processes [2]. Recent studies have identified morphological characteristics likely to be associated with a plaque's tendency to rupture, underlining the possibility of using such hallmarks clinically to predict, control and monitor . . . [Full Text of this Article]



   Activation of the renin–angiotensin system in atherosclerosis
 


   Why block the renin–angiotensin system in atherosclerosis?
 
ACE inhibitors in atherosclerosis
AT1 antagonists in atherosclerosis


   Conclusion
 

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