Nephrol Dial Transplant (2004) 19: 521-524
Nephrol Dial Transplant Vol. 19 No. 3 (c) ERA-EDTA 2004; all rights reserved
Editorial Comment
Hepcidin: a molecular link between inflammation and anaemia
Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
Correspondence and offprint requests to: Robert Deicher, Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Währinger Gürtel 18–20, 1090 Vienna, Austria. Email: robert.deicher@nephro.imed3.akh-wien.ac.at
Keywords: anaemia; hepcidin; inflammation
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Introduction |
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Hepcidin is a small, cysteine-rich cationic peptide that was purified only recently from human urine and plasma ultrafiltrate [1,2]. It forms a short hairpin with the two arms linked by four disulfide bridges in a ladder-like fashion. One of the disulfide bridges lies between two adjacent cysteine residues near the turn of the hairpin. The peptide appears to be conserved among species, and, due to its unusual disulfide motifs, it may represent a new class of antimicrobial peptides [3]. In mice, hepcidin mRNA was found to be induced by iron overload as well as by treatment with lipopolysaccharide [4]. Hence, a role in iron homeostasis and acute phase response was suggested. Nicolas et al. [5] submitted the idea that hepcidin constitutes a humoral factor regulating intestinal iron absorption and iron storage in macrophages. Because loss of hepatic hepcidin expression in
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Hepcidin: targeting duodenal enterocytes |
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Hepcidin: targeting monocytic cells? |
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Hepcidin: a target for erythropoietin? |
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Hepcidin: a possible target for nephrologists? |
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Conclusion |
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