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NDT Advance Access originally published online on August 24, 2004
Nephrology Dialysis Transplantation 2004 19(11):2709-2712; doi:10.1093/ndt/gfh480
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Nephrol Dial Transplant Vol. 19 No. 11 © ERA-EDTA 2004; all rights reserved

Hypothesis

Uraemic xerosis

Jacek C. Szepietowski1, Adam Reich1 and Robert A. Schwartz2

1 Department of Dermatology, Venereology and Allergology, University of Medicine, Wroclaw, Poland and 2 Department of Dermatology, New Jersey Medical School, New Jersey, USA

Correspondence and offprint requests to: Professor Jacek C. Szepietowski, MD, PhD, Department of Dermatology, Venereology and Allergology, University of Medicine, Ul. Chalubinskiego 1, 50-368 Wroclaw, Poland. Email. jszepiet@derm.am.wroc.pl

Keywords: emollients; haemodialysis; uraemic pruritus; uraemic xerosis

The first 150 words of the full text of this article appear below.

Introduction

Xerosis (rough and scaly skin) is a common chronic dermatological complication among patients undergoing maintenance renal dialysis (MRD) [1–3]. Although uraemic xerosis can also be observed in subjects with chronic renal failure before dialysis is needed, a significant increase in frequency of xerosis is observed when patients initiate dialysis. Furthermore, in the majority of cases, it typically disappears after renal transplantation. Interestingly, it is classically absent in acute renal failure, and is not correlated with the plasma urea level.

Uraemic xerosis was suggested to be an important factor influencing uraemic pruritus [1,3,4]. Based on large published series, xerosis of moderate to severe intensity leads to a 50–100% increase in uraemic pruritus [3,5,6]. Moreover, some investigators postulated that the uraemic pruritus level is directly related to xerosis severity; the more intense the xerosis, the greater the amount . . . [Full Text of this Article]

Frequency of uraemic xerosis

Clinical manifestation

Psychological impact of uraemic xerosis

Pathogenesis of uraemic xerosis

Uraemic xerosis and uraemic pruritus

Treatment of uraemic xerosis

Conclusions


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