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Nephrol Dial Transplant (2004) 19: 26-29
© European Renal Association–European Dialysis and Transplant Association

Editorial Comment

Flowing time on the peritoneal membrane

Michele Buemi1, Carmela Aloisi1, Giuseppa Cutroneo2, Lorena Nostro1 and Alessandro Favaloro2

1Department of Internal Medicine and 2Institute of Human Anatomy, Messina, Italy

Correspondence and offprint requests to: Prof. Michele Buemi, Via Salita Villa Contino 30, I-98100 Messina, Italy. Email: buemim@unime.it

Keywords: ageing; biocompatibility; peritoneal dialysis; ultrafiltration

The first 10% of the full text of this article appears below.



   Introduction
 
Time, passing on, rhythms our lives. This observation also applies to physiology and pathophysiology. It is known that this seasonal adaptability is based both on genetic programmes, and on a strict neurovegetative and endocrinological control, with a flexible and sophisticated network of activities changing in relation to external stimuli and aging, starting in intrauterine life to the years of growth, adulthood and senility. Likewise, the peritoneum of peritoneal dialysis (PD) patients responds to the passing of time by undergoing anatomical and functional changes (Figure 1).


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  		Fig. 1. Light microscope: 18 years old (a–b). One micrometre-thick sections, coloured with toluidine blue. Some fields show flat mesothelial cells (a); in other fields one can observe cells becoming cubic with very tight junction between them (b) (x750). 69 years old (c). One micrometre-thick section, coloured with . . . [Full Text of this Article]

 


   Factors involved in peritoneal ultrafiltration failure
 


   Structural and functional changes of peritoneal wall
 


   Potential therapeutic strategies
 


   Future perspectives
 


   Conclusion
 

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