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Nephrol Dial Transplant (2004) 19: 20-22
© ERA–EDTA 2003; all rights reserved

Editorial Comment

Erythropoietin: is it more than correcting anaemia?

Ferdinand H. Bahlmann, Kirsten de Groot, Hermann Haller and Danilo Fliser

Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany

Correspondence and offprint requests to: Danilo Fliser, MD, Department of Internal Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. Email: fliser.danilo@mh-hannover.de

Keywords: anaemia; cardiovascular regeneration; endothelial progenitor cells; erythropoietin; pleiotropic effects

The first 10% of the full text of this article appears below.



   The ‘old’ hormone erythropoietin
 
Erythropoietin (Epo) is a glycoprotein with a molecular weight of 30.4 kDa. The gene for Epo encodes a protein precursor of 193 amino acids, which after cleavage of a 27 amino acid sequence, glycosylation of four amino acids and removal of the C-terminal arginine yields the final circulating Epo molecule with 165 amino acids. The tertiary Epo structure is defined by four antiparallel {alpha}-helices and the binding of a single molecule to two adjacent Epo receptors on the membrane of target cells triggers intracellular signalling cascades. In the healthy adult, Epo is mainly produced in the kidney in response to hypoxia. The production of circulating Epo is regulated in order to maintain an . . . [Full Text of this Article]



   Emerging new facets of Epo's ego
 


   Epo and endothelial progenitor cells
 

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