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Nephrol Dial Transplant (2003) 18: 1703-1706
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

An update on herpes virus infections in graft recipients

Markus Ketteler, Uta Kunter and Jürgen Floege

Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany

Correspondence and offprint requests to: Markus Ketteler, MD, Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany. Email: mketteler@ukaachen.de

Keywords: human herpes virus; immunosuppression; renal transplantation; viral infections

The first 150 words of the full text of this article appear below.

Introduction

Acute rejection rates after renal transplantation are steadily decreasing due to more effective immunosuppressive therapies. However, more powerful prevention of immunological damage to the kidney by increasing immunosuppression is a two-edged sword, as infectious complications tend to rise in such a setting. Viral infections significantly contribute to morbidity and mortality after renal transplantation [1], and the spectrum of some viral diseases may have changed in recent years. Rapid diagnosis, appropriate antiviral treatment and management of concurrent medications are warranted to prevent patients from potentially severe disease manifestations. This brief review will focus on current considerations concerning infections with human herpes viruses (HHV) and their treatment in renal transplant recipients.

Cytomegalovirus (HHV-5)

Cytomegalovirus (CMV) infection is the most prevalent viral infection in renal transplant recipients [2]. Depending on the individual serostatus, patients may develop either primary infection, superinfection or reactivation of CMV infection. Seropositive transplant recipients with detectable CMV-IgG-antibodies . . . [Full Text of this Article]

Herpes simplex (HHV-1 and -2)

Varicella zoster (HHV-3)

Epstein–Barr virus (HHV-4) and HHV-8

HHV-6 and HHV-7

Conclusions


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