Nephrol Dial Transplant (2003) 18: 1434-1438
© 2003 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Oligonephronia, primary hypertension and renal disease: ‘is the child father to the man?’
Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, the University of Alabama at Birmingham, AL, USA
Correspondence and offprint requests to: Stephen G. Rostand, MD, Nephrology Research and Training Center, Division of Nephrology, Department of Medicine, the University of Alabama at Birmingham, Birmingham, AL 35294, USA. Email: srostand@uab.edu
Keywords: oligonephronia; primary hypertension; renal disease
| The first 150 words of the full text of this article appear below. |
In the US hypertension has been estimated to affect >40 million, or 
24% of the population [1]. Numerous physiologic, biochemical, genetic, developmental and environmental factors, including socio-economic, are felt to influence levels of blood pressure. However, the relative importance of these biologic and environmental forces and when in the course of human life they exert their influences are uncertain. It has been suggested that environmental forces occurring in early childhood, including those affecting intra-uterine growth and development, may pre-programme the organism for subsequent hypertension, cardiovascular and renal disease [2,3]. In this regard, a large body of evidence has demonstrated statistical associations between low birth weight and/or gestational age and hypertension, on the one hand, as well as cardiovascular and renal disease in adults and in children on the other [4–8]. A recent study by Keller et al. [9
Birth weight and nephron number
Is birth weight associated with blood pressure and renal disease risk?
Nephron number and disease
Early detection of renal dysfunction and subsequent renal risk
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