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Nephrol Dial Transplant (2003) 18: 1245-1248
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

Functional changes in the ageing kidney: is there a role for asymmetric dimethylarginine?

Jan T. Kielstein1,, Stefanie M. Bode-Böger2, Hermann Haller1 and Danilo Fliser1

1 Department of Internal Medicine, Medical School Hannover and 2 Institute of Clinical Pharmacology, Otto-von-Guericke University Magdeburg, Germany

Keywords: elderly; glomerulosclerosis; hypertension; renal perfusion; renovascular esistance

The first 10% of the full text of this article appears below.

Age-related changes of renal haemodynamics

Normal human ageing occurs with morphological and functional changes in nearly all organ systems, and the kidney is no exception to this rule. Even in individuals without primary renal disease, kidney structure and function deteriorate with senescence to some extent. Recent studies have revealed, however, that age-related renal changes are accelerated by co-morbid conditions such as hypertension, atherosclerosis and heart failure [1–5].

Results from the seminal ‘Baltimore Longitudinal Study on Aging’ and from several cross-sectional studies have shown that the decrease of glomerular filtration rate (GFR) in healthy elderly subjects is less than was thought previously [1,3,6,7]. In some . . . [Full Text of this Article]

Ageing and asymmetric dimethylarginine

Asymmetric dimethylarginine and renal ageing


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