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Nephrol Dial Transplant (2003) 18: 1039-1041
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

C-reactive protein and cardiovascular risk: an update on what is going on in cardiology

Wolfgang Koenig

Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany

Keywords: C-reactive protein; cardiovascular risk; clinical relevance; mechanisms

The first 150 words of the full text of this article appear below.

C-reactive protein and cardiovascular risk prediction: what is already known

The role of elevated high-sensitivity (hs) C-reactive protein (CRP) as a risk marker for cardiovascular (CV) diseases, including coronary heart disease (CHD) [1], stroke [2] and peripheral arterial disease [3] is well established through consistent results from a number of prospective studies. But CRP also conveys important prognostic information in the setting of the acute coronary syndrome. Subjects presenting with unstable angina or non ST-elevation myocardial infarction (MI) and increased levels of hs-CRP are candidates for a variety of adverse events like recurrent angina, ST elevation MI or coronary death. This holds true short-term for in-hospital complications but also long-term over years as has recently convincingly been shown by data from the FRISC trial [4]. Even in the presence of the results of troponin measurements, hs-CRP adds relevant prognostic information [5]. Moreover, persistent elevation of hs-CRP levels after optimal treatment . . . [Full Text of this Article]

New findings in primary prevention

New associations with CRP relevant to cardiology

New-onset type 2 diabetes
The insulin resistance syndrome
Renal insufficiency
Obstructive sleep apnea
Persistent atrial fibrillation
Air pollution
CRP: risk marker or risk factor?

Conclusions


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[Abstract] [Full Text] [PDF]