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Nephrol Dial Transplant (2003) 18: 477-478
© 2003 European Renal Association-European Dialysis and Transplant Association

Congress Report

Third International Meeting on Cyclooxygenase-2—Basic Research and Therapeutic Use, Regensburg, Germany, June 7–8, 2002

Bernhard K. Krämer

Klinik und Poliklinik für Innere Medizin II, Nephrologie, Klinikum der Universität, University of Regensburg, Germany Email: bernhard.kraemer@klinik.uni-regensburg.de

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Sixty scientists discussed recent progress in cyclooxygenase-2 (COX-2) research at the Third International Meeting on Cyclooxygenase-2. K. Brune, Erlangen, showed that besides mediation of peripheral inflammation and pain (e.g. via nociceptors) PGE2 production is increased in the spinal cord during peripheral pain (i.e. rat paw oedema), due to increased COX-2 expression. PGE2 inhibits, via the EP2 receptor inhibitory neurons in the dorsal horn of the spinal cord. M. Turini, Lausanne, discussed the role of prostaglandins in tumourigenesis/malignancy. PGE2 is antiapoptotic, whereas COX-2 blockade is proapoptotic. COX-2 blockade may even be effective in cell lines that . . . [Full Text of this Article]


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