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Nephrol Dial Transplant (2003) 18: 469-470
© 2003 European Renal Association-European Dialysis and Transplant Association

Hypothesis

Comment on hypothesis

Yvon Lebranchu

Tours Medical School, Nephrology and Immunology, Tours, France

Keywords: calcineurin inhibitors; dendritic-cell maturation; effects on; IL-2 secretion by dendritic cells; immunology; T-cell activation

The first 10% of the full text of this article appears below.

It is well known that, depending on their state of maturation, dendritic cells can activate T cells or render them tolerant. Dendritic cells leave the organ in response to inflammatory stimuli after grafting, migrate to secondary lymphoid organs and then mature. Activation of naive T cells by immature dendritic cells induces tolerance. The factors . . . [Full Text of this Article]


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