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Nephrol Dial Transplant (2003) 18: 467-468
© 2003 European Renal Association-European Dialysis and Transplant Association

Hypothesis

Dendritic cells and the mode of action of anticalcineurinic drugs: an integrating hypothesis

Alberto Fierro1,, J. Rodrigo Mora2,3, Maria Rosa Bono2, Jorge Morales1, Erwin Buckel1, Daniela Sauma2 and Mario Rosemblatt2,3

1 Clinica las Condes, Transplantation Unit, Santiago, 2 Universidad de Chile, Facultad de Ciencias, Immunology Laboratory, Santiago, Chile, 3 Fundación Ciencia para la Vida and Millennium Institute for Fundamental and Applied Biology, Santiago, Chile

Keywords: anticalcineurinic drugs; cyclosporin A; dendritic cells; IL-2; tacrolimus; transplantation immunology

The first 10% of the full text of this article appears below.

Despite important advances in the understanding of the immunobiology of allotransplantation and the mechanism of action of immunosuppressive drugs, recent reports have challenged our current understanding of these phenomena.

Until now, the mode of action of cyclosporin A (CsA) and tacrolimus (FK506) has been mainly ascribed to their remarkable capacity to act upon T lymphocytes by inhibiting the production of IL-2 and IFN-{gamma}, two cytokines required for the initiation and maintenance of T-lymphocyte responses in allograft rejection [1–3].

It is well recognized . . . [Full Text of this Article]


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Comment on hypothesis
Nephrol. Dial. Transplant., March 1, 2003; 18(3): 469 - 470.
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