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Nephrol Dial Transplant (2003) 18: 460-462
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Hyperglycaemia and renal ischaemia–reperfusion injury

Jan Melin, Olof Hellberg and Bengt Fellström

Department of Medical Sciences, Uppsala University, University Hospital, Uppsala, Sweden

Keywords: acute renal failure; diabetic nephropathy; hyperglycaemia; ischaemia–reperfusion injury; radiocontrast media; renal ischaemia

The first 10% of the full text of this article appears below.

Introduction

Hyperglycaemia is most probably a contributing factor in the development of ischaemic acute renal failure (ARF) in many patients. Both clinical and experimental data suggest that hyperglycaemia increases the risk of ARF [1–3]. Hyperglycaemia also worsens the outcome in renal transplantation [4,5]. Conversely, ischaemia–reperfusion (I/R) combined with hyperglycaemia could also be important in the development of diabetic nephropathy. Studies in our laboratory show that a brief renal ischaemia results in a progressive injury leading to end-stage renal failure in diabetic animals [6,7]. The mechanisms behind this increased sensitivity to renal I/R during hyperglycaemia are still poorly understood.

Experimental findings

An increased susceptibility to renal I/R injury in diabetic rats has been shown in several studies [1,3,6–9]. Furthermore, non-diabetic rats and dogs are more vulnerable . . . [Full Text of this Article]

Clinical observations

Critically ill patients
Kidney transplantation
Hyperglycaemia and radiocontrast media
Pathophysiology

Diabetic nephropathy

Prevention

Conclusion


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