Nephrol Dial Transplant (2003) 18: 2474-2478
© 2003 European Renal Association-European Dialysis and Transplant Association
Editorial Comment
Senescence of renal cells: molecular basis and clinical implications
Division of Nephrology and Immunology, University of Alberta, Edmonton, Canada
Correspondence and offprint requests to: Anette Melk, MD, PhD, Division of Nephrology and Immunology, University of Alberta, 250 Heritage Medical Research Centre, Edmonton, Alberta, T6G 2S2, Canada. Email: anettemelk@yahoo.de
Keywords: allograft nephropathy; cellular senescence; kidney ageing; p16INK4a; renal senescence; telomere
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Introduction |
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Age-associated changes of the kidney are important not only because normal ageing alters renal function but also because of the high frequency of end-stage renal disease in the elderly (ERA–EDTA Registry Report 2000). Old kidneys perform poorly when transplanted, and donor age is a major determinant of graft survival [1]. It has been proposed that interactions between ageing and diseases may contribute to these problems. Understanding the mechanisms of declining organ function with age may be instructive concerning the mechanisms of decline in disease states, since stress might accelerate ageing changes. Kidney ageing is also of interest as a general model for organ ageing, because renal function can be assessed with relative ease in clinical practice and has been quantified in longitudinal studies [2]. The molecular basis of ageing changes in organs is not known, but organ ageing may reflect aspects of cellular senescence which are
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Terms and definitions |
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The phenotype of renal senescence |
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Mechanisms of cellular senescence and their relevance for renal senescence |
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Replicative senescence and telomeres
Cellular senescence reached by other mechanisms
Cellular senescence in vivo
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Implications for nephrology and transplantation |
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