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Nephrol Dial Transplant (2003) 18: 1976-1979
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

Interleukin-10 (IL-10): an update on its relevance for cardiovascular risk

Matthias Girndt and Hans Köhler

Medical Department IV, University of the Saarland, Homburg/Saar, Germany

Correspondence and offprint requests to: PD Dr M. Girndt, Medical Department IV, University of the Saarland, Kirrberger Strasse 1, D-66421 Homburg/Saar, Germany. Email: inmgir@uniklinik-saarland.de

Keywords: atherosclerosis; chronic renal failure; end-stage renal disease; inflammation; interleukin-10

The first 150 words of the full text of this article appear below.

Inflammation plays a major role in the pathogenesis of atherosclerotic lesions of vascular walls. This concept, initially promoted by Ross [1], was confirmed by several lines of evidence in recent years. Components of the inflammatory system were found in the atheromatous plaque, a relation between lipid metabolism, endothelial damage and inflammation was pointed out, and progression or instability of cardiovascular disease is associated with a systemic inflammatory response. These findings directed attention towards interleukin (IL)-10 as one of the most important mediators that physiologically limits and down-regulates inflammation. Indeed, IL-10 proved to have several protective features acting against atherosclerotic disease. Interest in this cytokine was further strengthened by its role in patients with chronic renal failure, in whom a very high level of systemic inflammation is associated with an enormous burden of cardiovascular morbidity.

Inflammation and atherosclerosis

The Physicians Health Study introduced CRP as a parameter for systemic inflammation in asymptomatic . . . [Full Text of this Article]

IL-10 and cardiovascular disease

IL-10 in cardiovascular disease of end-stage renal disease


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