Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Erwig, L.-P.
Right arrow Articles by Rees, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Erwig, L.-P.
Right arrow Articles by Rees, A. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2003) 18: 1962-1965
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

Macrophage heterogeneity in renal inflammation

Lars-Peter Erwig, David C. Kluth and Andrew J. Rees

Department of Medicine and Therapeutics, University of Aberdeen, UK

Correspondence and offprint requests to: Dr Lars-Peter Erwig, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Email: L.P.Erwig@abdn.ac.uk

Keywords: activation; inflammation; glomerulonephritis; macrophage

The first 150 words of the full text of this article appear below.

Introduction

Macrophages evolved to maintain and restore tissue integrity. They originate from bone marrow-derived precursors and traffic through tissues where they have essential roles in remodelling during fetal development; in host defence against infection and tumours; and in wound healing [1]. Macrophages also mediate injury in immune-mediated diseases including glomerulonephritis, and this aspect of their function together with their role in combating infection have tended to overshadow their involvement in tissue repair. Understanding how macrophage function adapts to the needs of particular microenvironments is a principal challenge for inflammatory cell biologists. Importantly, learning to manipulate macrophage function to promote their reparative properties would be a powerful therapeutic tool, a point emphasized by the recognition that many viruses, parasites and tumour cells have evolved to redirect macrophage function to promote their survival [2]. Our purpose here is to review briefly what is known about the role of macrophages . . . [Full Text of this Article]

Macrophages and renal injury

Macrophage activation

Macrophage programming

Macrophage activation in vivo

Effect of genetically modified macrophages on renal inflammation

Conclusion


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
V. Ninichuk, S. Clauss, O. Kulkarni, H. Schmid, S. Segerer, E. Radomska, D. Eulberg, K. Buchner, N. Selve, S. Klussmann, et al.
Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36-3'PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice
Am. J. Pathol., March 1, 2008; 172(3): 628 - 637.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
V. Ninichuk, A. G. Khandoga, S. Segerer, P. Loetscher, A. Schlapbach, L. Revesz, R. Feifel, A. Khandoga, F. Krombach, P. J. Nelson, et al.
The Role of Interstitial Macrophages in Nephropathy of Type 2 Diabetic db/db Mice
Am. J. Pathol., April 1, 2007; 170(4): 1267 - 1276.
[Abstract] [Full Text] [PDF]