Nephrol Dial Transplant (2003) 18: 27-32
© 2003 European Renal Association-European Dialysis and Transplant Association
Invited Comment
Inflammation modifies lipid-mediated renal injury
Centre for Nephrology, Royal Free and University College Medical School, University College London, Royal Free Campus, London, UK
Keywords: dyslipidaemia; focal and segmental glomerulosclerosis; progressive renal disease
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Introduction
Clinical findings in humans suggest, and experimental studies in animal models demonstrate, that dyslipidaemia can lead to disease progression and glomerulosclerosis [1,2]. Thus, it has been established that cholesterol supplementation of the diets of several animal species leads to focal and segmental glomerulosclerosis (FSGS) [3–7] and foam cells and lipid deposits are found in focal segmental sclerosis in human renal biopsies [8]. Many of the features of progressive glomerular and tubulo-interstitial diseases share biological mechanisms with those of atherosclerosis [9,10], which affects both large and medium sized arteries and the microvasculature, as well as in progressive renal disease. A consequence of this shared pathology has led to the use of lipid-lowering drugs to assess the contribution of hyperlipidaemia to the progression of renal damage [11].
Although many animal models of diet-induced hyperlipidaemia support the
Atherosclerosis as an inflammatory disease
Inflammation modifying lipid-mediated renal injury
Lipid-mediated inflammatory signals
Inflammation may also accelerate lipid-mediated renal injury by affecting cholesterol metabolism
Inflammation accelerates lipid-mediated renal injury by affecting cholesterol homeostasis at the cellular level
Protective measures against inflammation
Conclusion
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Connotea 
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