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Nephrol Dial Transplant (2002) 17: 1543-1546
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

The role of genetic susceptibility in diabetic nephropathy: evidence from family studies

Stephen Fava1,2, and Andrew T. Hattersley2

1 Diabetes Clinic, St Luke's Hospital, Guardamangia, Malta and 2 Centre of Molecular Genetics, Institute of Clinical Science, University of Exeter, Exeter, UK

The first 150 words of the full text of this article appear below.

Introduction

Diabetic nephropathy is one of the long-term complications of both type 1 and type 2 diabetes. It is a leading cause of end-renal disease in many countries [1]. Furthermore, it is associated with increased cardiovascular mortality, with most of the excess mortality associated with diabetes being seen in those with nephropathy [2,3].

It is impossible to predict which diabetic patients will develop renal disease. Although duration of diabetes, tightness of glycaemic control, and blood pressure are undoubtedly implicated [4,5], these factors are insufficient on their own to predict which patients will develop the complication. Therefore, a patient with poor blood pressure and glycaemic control might not develop diabetic renal disease even many years after diagnosis of diabetes. Clearly, other factors must also be involved.

The prevalence of nephropathy associated with type 1 diabetes rises with increased duration but levels out . . . [Full Text of this Article]

Familial aggregation of diabetic nephropathy

Co-aggregation with other manifestations of the insulin-resistance syndrome (IRS)

Diabetic nephropathy and anthropometric parameters

Is diabetic nephropathy inherited separately from diabetes?

Conclusion


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