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Nephrol Dial Transplant (2002) 17: 719-722
© 2002 European Renal Association-European Dialysis and Transplant Association

Child - Adult Interface

Is atherosclerosis accelerated in young patients with end-stage renal disease? The contribution of paediatric nephrology

Uwe Querfeld

Department of Paediatric Nephrology, Charité Berlin, Berlin, Germany

Keywords: atherosclerosis; children; risk factors; renal osteodystrophy

Introduction

The concept of an acceleration of atherosclerosis due to end-stage renal disease (ESRD) was first proposed by Lindner et al. [1] who observed a very high incidence of myocardial infarction in the Seattle haemodialysis population in 1974. Subsequent studies have confirmed a high prevalence of atherosclerotic lesions in dialysis patients by autopsy [2], by in vivo examination of iliac artery specimens [3] and by coronary angiography [3,4]. Approximately 50% of mortality in the dialysis population is due to cardiovascular disease (CVD) and the risk of death from CVD is elevated 30-fold for patients with ESRD compared with the general population [5]. Similarly, the incidence of CVD is much increased after renal transplantation [6]. The epidemic of CVD in ESRD may be explained by a unique accumulation of risk factors for atherosclerosis [7]. However, . . . [Full Text of this Article]

Cardiac death in young patients

Risk factors in the young

Treatment of renal osteodystrophy in childhood: an iatrogenic risk factor?

Uraemic asteriopathy vs atheroma

Notes

References


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