Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Schmidt, A.
Right arrow Articles by Hörl, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmidt, A.
Right arrow Articles by Hörl, W. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2002) 17: 368-371
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Sexual hormone abnormalities in male patients with renal failure

Alice Schmidt1,, Anton Luger2 and Walter H. Hörl1

1 Division of Nephrology and Dialysis and 2 Division of Endocrinology, Department of Internal Medicine III, University of Vienna, Vienna, Austria

Introduction

Endocrine abnormalities are a common feature of chronic renal insufficiency [1,2]. Changes of androgen synthesis and metabolism develop early after the onset of renal insufficiency and are likely to be caused by primary hypogonadism and/or disturbances of the hypothalamic–pituitary axis. Uraemic toxins, co-morbidity, and concomitant drug administration are supposed to contribute to the observed changes, yet the exact mechanism remains unclear. Impaired function of the hypothalamic–pituitary–gonadal axis is not reversed by initiation of otherwise effective haemodialysis or peritoneal dialysis therapy. In contrast, renal transplantation was reported to restore endocrine function, but study results are conflicting. A complete normalization as well as persistingly low testosterone levels have been described after transplantation and gonadotrophin levels were also reported to be persistingly high or normal [3,4].

Pathophysiology and pathogenesis

In male patients with renal failure, plasma testosterone levels are decreased or in the low normal range in the . . . [Full Text of this Article]

Aetiology

Consequences of androgen deficit

Therapy

Side effects of androgen therapy

Progression of renal disease by androgens?

Notes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HypertensionHome page
Q. Xu, C. C. Wells, J. H. Garman, L. Asico, C. S. Escano, and C. Maric
Imbalance in Sex Hormone Levels Exacerbates Diabetic Renal Disease
Hypertension, April 1, 2008; 51(4): 1218 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
H. W. Daniell
Erythropoietin resistance during androgen deficiency.
Arch Intern Med, September 25, 2006; 166(17): 1923 - 1923.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. F. Reckelhoff, L. L. Yanes, R. Iliescu, L. A. Fortepiani, and J. P. Granger
Testosterone supplementation in aging men and women: possible impact on cardiovascular-renal disease
Am J Physiol Renal Physiol, November 1, 2005; 289(5): F941 - F948.
[Abstract] [Full Text] [PDF]