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Nephrol Dial Transplant (2002) 17: 356-359
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Erythropoietin, tumours and the von Hippel–Lindau gene: towards identification of mechanisms and dysfunction of oxygen sensing

Michael S. Wiesener and Kai-Uwe Eckardt

Department of Nephrology and Medical Intensive Care, Charité, Campus Virchow Klinikum, Humboldt University, Berlin, Germany

Keywords: erythropoietin; gene expression; hypoxia; hypoxia-inducible transcription factors; renal tumours; von Hippel–Lindau disease

Introduction

One of the central issues of physiology is the adaptation to alterations in supply or need of molecules that are essential for cellular functions. Mammalian and many non-mammalian organisms depend critically on oxygen for generation of energy that is required to maintain cellular structure and function. The adaptation to changes in oxygen supply and consumption includes alterations in oxygen uptake from the environment (respiration), its transport within the body (circulation), and the modulation of alternative pathways for energy production (anaerobic metabolism). Some of the immediate responses to changes in oxygen supply involve alterations in the conductance of ion channels. More sustained adaptation, however, is based on changes in cellular gene expression and protein synthesis. Considerable advances have been made recently in understanding the molecular mechanisms of oxygen dependent gene regulation and have led to exciting insights into their importance in the biology of renal and non-renal cancer.

Hypoxia-inducible transcription factors

The glycoprotein hormone . . . [Full Text of this Article]

The familial VHL cancer syndrome

VHL targets HIF for O2-dependent degradation

VHL loss of function exemplifies the importance of HIF

HIF as molecular target for intervention

Note added in proof

Notes

References


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