Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dechend, R.
Right arrow Articles by Luft, F. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dechend, R.
Right arrow Articles by Luft, F. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2002) 17: 349-353
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Statins and angiotensin II-induced vascular injury

Ralf Dechend, Dominik Müller, Jeun Koon Park, Anette Fiebeler, Hermann Haller and Friedrich C. Luft

HELIOS Klinikum Berlin, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany and the Department of Nephrology, Hannover Medical School, Hannover, Germany

Effects of statins unrelated to lipid lowering

Statins may have pleiotropic properties that complement their cholesterol-lowering effects. These properties include nitric oxide-mediated improvement of endothelial dysfunction and attenuation of endothelin-1 expression, antioxidant effects, anti-inflammatory properties, inhibition of cell proliferation with anti-carcinogenic actions in animals, stabilization of atherosclerotic plaques, anti-coagulant effects and inhibition of graft rejection after heart and kidney transplantation [1]. In a remarkable short-term human study, Tsunekawa et al. [2] showed that cerivastatin improved endothelial dysfunction in elderly diabetic men within 3 days, independent of lipid lowering. The effect may have been partly due to upregulation of nitric oxide (NO) production.

Angiotensin II-induced vascular injury—a model to study non-clinical effects of statins

We have been interested in angiotensin II (Ang II)-induced vascular injury and were curious to see if a statin would ameliorate the effects. We investigated this issue in a double transgenic rat . . . [Full Text of this Article]

Statins block the response to Ang II

The role of prenylation of Ras superfamily proteins

Effects of statins on endothelial cell function

Potential human relevance?

Notes

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
D. Susic, J. Varagic, J. Ahn, M. Slama, and E. D. Frohlich
Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models
J. Am. Coll. Cardiol., September 17, 2003; 42(6): 1091 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
C. Kluft, R. Kleemann, and M.P.M. de Maat
How best to counteract the enemies? By controlling inflammation in the coronary circulation
Eur. Heart J. Suppl., November 1, 2002; 4(suppl_G): G53 - G65.
[Abstract] [PDF]