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Nephrol Dial Transplant (2002) 17: 347-348
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Nitric oxide triggers the expression of proinflammatory and protective gene products in mesangial cells and the inflamed glomerulus

Josef Pfeilschifter

Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

Introduction

Nitric oxide (NO) is a double-edged sword. Synthesized in appropriate amounts by endothelial cells, neurons or macrophages it contributes to blood pressure regulation, neuronal communication and immune defence to name but a few important functions. On the other hand, excessive and uncontrolled production of NO by the inducible isoform of NO synthase (iNOS) is associated with several severe diseases like septic shock, stroke, neurodegeneration, diabetes, arthritis and other forms of chronic inflammation. The kidney does not escape from the impact of NO. I will highlight how increased understanding of . . . [Full Text of this Article]

Mesangial iNOS expression and the role of NO

Targets of NO action

Induction of cellular defence or cell death?

Notes

References


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