Nephrol Dial Transplant (2002) 17: 198-200
© 2002 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
End-stage renal failure in African Americans: insights in kidney disease susceptibility
Section on Nephrology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Epidemiology
The aetiologies of the markedly increased incidence rate of end-stage renal failure (ESRF) among African-, Native-, Hispanic-, and Asian Americans, relative to European Americans, continue to be debated. Much has been learned about the impact that African American (black) race has on the biologic and sociocultural aspects of systemic diseases predisposing to ESRF. This information may prove useful in determining the causes of the unique susceptibility to kidney disease that is observed in the American black population. In aggregate, blacks have lower socioeconomic status (SES) with poorer access to medical care than do whites. However, well-designed analyses reveal that lower SES and greater severity of hypertension and hyperglycaemia fail to fully account for their excess rate of ESRF [1–3].
Racial variation in hypertension and diabetes
In the US, hypertension-associated ESRF (H-ESRF) exhibits the largest black to
Putative renal failure susceptibility genes
Conclusions
Notes
References
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