Nephrol Dial Transplant (2002) 17: 2041-2043
© 2002 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
No lupus nephritis in the absence of antiC1q autoantibodies?
1 Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France, 2 INSERM U507, Hôpital Necker, France and 3 University Hospital Basel, Medizinische Universitätsklinik B, Kantonsspital Basel, Basel, Switzerland
Keywords: antiC1q autoantibodies; biological markers; lupus nephritis; renal relapse; systemic lupus erythematosus
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One of the characteristics of systemic lupus erythematosus (SLE) is the large inter- and intra-individual variability of the clinical course. Lupus nephritis is no exception. Some patients with kidney involvement may show rapid progression to renal failure, while others may enter complete and stable remission after adequate therapy. More difficult to manage are the large number of patients who have similar clinical and histological patterns at presentation, but alternate periods of clinical quiescence with renal relapses of different severity. It is still uncertain which, if any, immunologic parameters may help to diagnose a renal flare. The increase in anti double-stranded DNA (dsDNA) titre or hypocomplementaemia related to classical pathway activation provides no indication as to whether a relapse includes the kidney. Here
Classical pathway of complement activation
SLE and antiC1q antibodies
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