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Nephrol Dial Transplant (2002) 17: 1875-1878
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Vitamin D deficiency: a neglected aspect of disturbed calcium metabolism in renal failure

Jorge B. Cannata-Andía and Carlos Gómez Alonso

Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación, Hospital Central de Asturias, Universidad de Oviedo, Oviedo, Spain

Keywords: 25(OH)D3; secondary hyperparathyroidism; vitamin D; vitamin D insufficiency; vitamin D normal cut-off levels

The first 150 words of the full text of this article appear below.

The vitamin D hormonal system

The vitamin D hormonal system comprises different metabolites derived from the precursor cholecalciferol (vitamin D3), which is generated by actinic synthesis in the skin (under the influence of UV light) or is of dietary origin. Endogenous vitamin D belongs to the vitamin D3 series, while some vitamin D supplements belong to the vitamin D2 series. The latter (ergocalciferol) is of plant origin. In a first step these precursors are hydroxylated in the liver, thus forming the metabolite 25-hydroxy-vitamin D [25(OH)D] with a long half-life (3–4 weeks). 25(OH)D is a substrate for enzymes producing further vitamin D metabolites. 25(OH)D is the best indicator of vitamin D status [1]. By the action of 1-alpha-hydroxylase the most active metabolite 1,25-dihydroxyvitamin D or calcitriol is produced mainly in the kidney, but also in some extrarenal tissues. It has a short half-life (hours) and acts upon receptors in different target organs, both . . . [Full Text of this Article]

Importance of 25(OH)D

Factors influencing 25(OH)D concentrations

Re-defining normal serum concentrations of 25(OH)D

The advantage of paying close attention to 25(OH)D3 concentration


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