Nephrol Dial Transplant (2002) 17: 1713-1724
© 2002 European Renal Association-European Dialysis and Transplant Association
Tony Raine Memorial Lecture
Arterial structure and function in end-stage renal disease
Nephrology Department, Manhès Hospital, Fleury-Mérogis, France
| The first 150 words of the full text of this article appear below. |
On October 14, 1995, Professor A. Raine (St Bartholomew's Hospital, London) died at the young age of 46 years. He was a fascinating man who combined a rigorous scientific approach with clinical acumen. He excelled in the fields of hypertension research and nephrological research. He was an inspired investigator whose untimely death is mourned by many colleagues in European nephrology.
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NDT commemorates the outstanding contributions of our former subject editor in the field of hypertension by a contribution bearing on the major research topic of the late Professor Raine, i.e. the interrelation of kidney and blood pressure.
Introduction
Epidemiological studies have shown that damage of large conduit arteries is a major contributing factor to morbidity and mortality in patients with chronic kidney disease and in those with end-stage renal disease (ESRD) [1]. Atherosclerosis, a primary intimal disease characterized by the presence of plaques
Arterial remodeling and arterial function: basic concepts
Arterial remodeling
Arterial function
Conduit function of arteries
Cushioning (dampening) function of arteries
Arterial stiffness, blood pressure and cardiovascular disease in ESRD
Consequences of arterial stiffening in ESRD patients
Pathophysiological consequences
The clinical consequences
Therapeutic interventions on arterial stiffness and their impact on patient outcome
Conclusions
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