Nephrol Dial Transplant (2002) 17: 17-19
© 2002 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Influencing the inflammatory response of haemodialysis patients by cytokine elimination using large-pore membranes
Department of Nephrology and Internal Intensive Care Medicine, Charité-Campus Virchow-Klinikum, Humboldt University of Berlin, Berlin, Germany
Keywords: C-reactive protein; cardiovascular risk; inflammatory mediators
Inflammatory mediators and cardiovascular risk
Over recent years an association between cardiovascular events and inflammation has been reported by several groups and this now finally appears to be well established. Baseline levels of C-reactive protein (CRP) in apparently healthy individuals represent an independent risk factor for cardiovascular events including myocardial infarction and peripheral artery disease [13]. Moreover, the rise in CRP after myocardial infarction, or during unstable angina pectoris, predicts outcome [4]. It has been suggested that the inflammatory process may not merely be an epiphenomenon but rather a pathogenetical factor in the genesis of atherosclerosis [5].
Cardiovascular mortality is greatly increased in haemodialysis patients. For instance, the risk of dying from cardiovascular causes is 100-fold
Removal of mediators by extracorporeal treatment
Need for prospective studies
Notes
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