Nephrol Dial Transplant (2001) 16: 1735-1738
© 2001 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Cyclooxygenase-2 and macula densa control of renin secretion
National Institute of Diabetes, Digestive and Kidney Disease, NIH, Bethesda, Maryland, USA
Keywords: angiotensin II; cyclooxygenase-2
Prostaglandins and the secretion of renin
The tubular and cardiovascular effects of angiotensin II combine to make it one of the most important effectors of body Na conservation and blood pressure maintenance. Control of renin secretion, the rate-limiting step in the formation of angiotensin II, is therefore of critical importance for extracellular fluid volume and blood pressure homeostasis. Among the many factors that can alter renin secretion, special attention has been paid to the role of prostaglandins (PGs) as paracrine mediators because plasma and secretion levels of renin correlate directly with PG production in many clinical and experimental conditions. Covariation of renin and PG production is the result of a complex interaction that has the structure of a positive feedback relationship.
Initially it was found that angiotensin II as well as other Ca-liberating agents can augment the release of PGs into renal venous blood [1]. Numerous subsequent studies have confirmed that angiotensin II enhances
Cyclooxygenases in juxtaglomerular cells
Cyclooxygenase-2 and macula densa control of renin release and expression
Mechanisms of COX-2 regulation by low NaCl transport
Conclusion
Notes
References
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