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Nephrol Dial Transplant (2001) 16: 1329-1335
© 2001 European Renal Association-European Dialysis and Transplant Association

Invited Comment

The epithelial calcium channel, ECaC1: molecular details of a novel player in renal calcium handling

Dominik Müller, Joost G. J. Hoenderop, Carel H. van Os and René J. M. Bindels

Department of Cell Physiology, University Medical Centre Nijmegen, The Netherlands

Keywords: calcitriol; kidney; duodenum; ECaC2; CaT1; calcium absorption

Introduction

The recent identification of the epithelial Ca2+ channel, ECaC1, in the kidney represents a major step forward in our knowledge of renal Ca2+ handling. This membrane channel protein is the first member of a new family of Ca2+-selective cation channels. It consists of six transmembrane-spanning domains, including a pore-forming hydrophobic stretch between domains 5 and 6. ECaC1 constitutes the apical entry mechanism of active, transcellular Ca2+ reabsorption. In contrast to the paracellular route, this transcellular pathway enables the organism to actively control the net amount of Ca2+ reabsorption. In vivo studies indicate a specific regulation of ECaC1 by calcitriol. This novel Ca2+ channel is also expressed in other tissues like intestine, pancreas, brain, testis and prostate. The central role of ECaC1 in active Ca2+ reabsorption makes it a prime target for pharmacological manipulation, and several disorders related to Ca2+ homeostasis could benefit from such developments. This review highlights the . . . [Full Text of this Article]

Calcium handling by the kidney

Molecular details of the epithelial calcium channel, ECaC1

ECaC1 homologues

Clinical implications

Conclusion

Acknowledgments

Notes

References


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