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Nephrol Dial Transplant (2001) 16: 1324-1328
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Renal problems after lung transplantation of cystic fibrosis patients

Ralf Schindler1,, Cornelia Radke2, Karl Paul3 and Ulrich Frei1

1 Department of Nephrology and Internal Intensive Care Medicine, 2 Department of Pathology and 3 Department of Pediatric Pulmonology, Universitätsklinikum Charité, Campus Virchow Klinikum, Berlin, Germany

Keywords: cystic fibrosis; diabetes mellitus; lung transplantation; nephrotoxicity; renal failure

Introduction

Routine monitoring and early intervention (antibiotics, high calorific intake, pancreatic enzymes and physiotherapy) have increased the life expectancy of cystic fibrosis (CF) patients from 14 years in 1969 to 30 years in 1995 [1]. In 2000, 40% of these patients are adults [2]. Renal function is not affected primarily in CF (except for a reduced capacity to secrete sodium chloride), but the kidney may be involved secondarily in later life. With the increasing numbers of CF patients receiving a lung or a lung/heart transplant, and with the improving results of the transplant procedure, nephrologists are faced with more and more of these patients suffering from renal failure.

Recently, Broekroelofs et al. investigated the long-term renal outcome in 57 patients after lung transplantation [3]. The loss in glomerular filtration rate (GFR) after transplantation was greater for seven CF patients compared with patients with primary . . . [Full Text of this Article]

Drug toxicity

Diabetes mellitus

Nephrocalcinosis

Case report
Perspectives

Notes

References


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