Nephrol Dial Transplant (2001) 16: 1095-1097
© 2001 European Renal Association-European Dialysis and Transplant Association
Editorial Comment
Drug treatment of isolated systolic hypertension
Departments of Pharmacotherapy, Cardiology and Cardiothoracic Surgery, Academic Medical Centre, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Introduction
Until the 1980s diastolic blood pressure (DBP) was assumed to be the most relevant haemodynamic parameter as a predictor of prognosis in hypertensive patients. Accordingly, most clinical studies particularly addressed DBP, and DBP-values were put forward as goals for treatment [1]. Since then a radical change in thinking, based upon epidemiological studies has led to the recognition of elevated systolic blood pressure (SBP) as a risk factor at least as important as high DBP [1–5]. Certain studies would even indicate that SBP is a more relevant predictor of prognosis than DBP, in particular with respect to the risk of stroke [1]. For this and other reasons, the term ‘isolated systolic hypertension’ (ISH) has been introduced for those subjects with elevated SBP and normal (or even lower) DBP. This condition is found particularly in elderly hypertensives, since SBP is known to
Isolated systolic hypertension as a risk factor
Benefit of treatment of ISH
Systolic Hypertension in the Elderly Program (SHEP) ]14[
Systolic Hypertension in Europe (SYST-EUR) [15]
SYST-China trial [17]
INSIGHT study [18]
New approaches in the treatment of ISH
Conclusions and recommendations
Notes
References
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Goldsmith, R. MacGinley, A. Smith, and A. Covic How important and how treatable is vascular stiffness as a cardiovascular risk factor in renal failure? Nephrol. Dial. Transplant., June 1, 2002; 17(6): 965 - 969. [Full Text] [PDF]
|
|