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Nephrol Dial Transplant (2001) 16: 888-890
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Hormone replacement therapy and blood pressure in normotensive and hypertensive women

Arya M. Sharma, Volker Homuth and Friedrich C. Luft

Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany

Keywords: cardiovascular risk; hormone replacement therapy; hypertension; menopause; oestrogens; women's health

Introduction

Oral contraceptives are one of the recognized causes of secondary hypertension, and although the condition occurs much less frequently with the preparations employed today compared with those used 20 years ago, clinicians continue to be concerned about the effects of hormonal preparations on blood pressure. Pregnancy is associated with a decrease in blood pressure. Nevertheless, apart from pre-eclampsia, certain women develop milder forms of pregnancy-associated hypertension that may be hormonally related. Thus, the possibility that hormone replacement therapy (HRT) might indeed increase blood pressure in at least some recipients, is a notion worth testing. Menopause affects half the citizenry at some point or other and the putative advantages of HRT in terms of cardiovascular and skeletal health, as well as wellbeing, comfort, and perhaps appearance, have received much attention. The likelihood that many if not most women will select HRT during or after menopause, to increase their survival superiority compared . . . [Full Text of this Article]

Putative mechanisms

Data from clinical trials

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References


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