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Nephrol Dial Transplant (2001) 16: 441-444
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Potential role of retinoids in the therapy of renal disease

Juergen Wagner

Department of Internal Medicine, University of Heidelberg, Germany

Keywords: retinoids; renal disease

Introduction

It is by now common knowledge that the processes of tissue injury and repair in renal disease do not depend on the action of single genes but involve a complex network of growth factors, cytokines, and vasoactive peptides that are further modulated by haemodynamic and metabolic factors. In this context retinoids, which are derivatives of vitamin A, have recently attracted attention as potential therapeutic agents. Their effects are pleiotropic, since retinoids modulate the function of several key transcription factors which are involved, among others, in damage and repair mechanisms that are operative in renal diseases. These considerations have raised hopes that the therapeutic potential of retinoids goes beyond dermatology and oncology to include also renal disease.

Retinoid system

It has long been known that retinol (vitamin A) is an essential component of the diet [1]. Both clinical and experimental studies documented that retinoids, i.e. biologically active derivatives of vitamin . . . [Full Text of this Article]

Retinoid receptors

Retinoid receptor action

Actions of retinoids with potential relevance to kidney disease

Outlook

Notes

References


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