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Nephrol Dial Transplant (2001) 16: 218-221
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Dietary Ca2+ and blood pressure: evidence that Ca2+-sensing receptor activated, sensory nerve dilator activity couples changes in interstitial Ca2+ with vascular tone

Richard Dean Bukoski

Cardiovascular Disease Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA

Introduction

It has been more than 20 years since Ayachi [1] showed that feeding Ca2+ to the spontaneously hypertensive rat lowers the animal's blood pressure. This finding, along with other seminal observations [2–4], sparked a burst of activity exploring the relationship between dietary Ca2+ intake and blood pressure regulation in human and animal models of hypertension. While the question of whether elevated Ca2+ intake lowers blood pressure in humans remains controversial [5,6], data showing an inverse correlation between Ca2+ intake and blood pressure in several models of hypertension in the rat and dog are consistent [7–11].

Over the past two decades, multiple mechanisms have been postulated to explain how increased Ca2+ intake lowers blood pressure. These range from diet-induced suppression of serum levels of calciotropic hormones, including 1,25 (OH)2 vitamin D3 and parathyroid hormone [12], . . . [Full Text of this Article]

Ca2+ and vascular relaxation

Interstitial Ca2+

The sensory nerve Ca2+sensing receptor: a potential molecular link

Summary and future perspectives

Acknowledgments

Notes

References


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