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Nephrol Dial Transplant (2001) 16: 213-215
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Glomerular hypertension—an under-appreciated aspect of chronic rejection

Leendert C. Paul

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands

Introduction

Loss of renal mass results in an increase in renal blood flow and single-nephron glomerular filtration rate in the remaining renal tissue. Increased flow rates are accomplished through dilatation of the afferent and efferent arterioles. The former dilate more than the latter, however. This causes an increase in glomerular capillary hydrostatic pressure (PGC). Although this response is apparently beneficial to maintain homeostasis despite reduction in renal mass, a large body of evidence suggests that sustained elevated PGC ultimately results in proteinuria, glomerulosclerosis, and further loss of nephrons [1]. In clinical transplantation, most patients receive only one donor kidney that often has incurred injury during the agonal phase of the donor, . . . [Full Text of this Article]

Glomerular hypertension and chronic rejection: clinical studies

Glomerular hypertension and chronic rejection: experimental studies

Interventions to lower the glomerular hydrostatic pressure

Conclusion

Notes

References


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