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Nephrol Dial Transplant (2001) 16: 2283-2285
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Cytochrome P450 metabolites of arachidonic acid: novel regulators of renal function

Kimberly M. Hoagland, Kristopher G. Maier, Carol Moreno, Ming Yu and Richard J. Roman

Department of Physiology, Medical College of Wisconsin, Milwaukee, USA

Keywords: arachidonic acid; cytochrome P450; regulation of renal function

Metabolism of arachidonic acid by cytochrome P450 enzymes

Recent studies indicate that in the kidney arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to produce epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acids (DiHETEs), and 19- and 20-hydroxyeicosatetrienoic acids (19- and 20-HETE). CYP450 metabolites of AA play a major role in the regulation of renal vascular tone, tubuloglomerular feedback (TGF), and sodium transport [1,2]. Enzymes of the CYP450 4A and 4F families catalyse the formation of 20-HETE. CYP450 4A mRNA and protein are expressed in the renal arterioles, glomerulus, proximal tubule (PT), cortical and medullary thick ascending limb of the loop of Henle (TALH), and in the pericytes surrounding vasa recta capillaries [2,3]. The renal arterioles, PTs, and glomeruli avidly produce 20-HETE, EETs, and DiHETEs when incubated with AA, while in the TALH, 20-HETE is the primary metabolite of AA [2].

Enzymes of the CYP450 1A, 2B, 2C, 2D . . . [Full Text of this Article]

CYP450 metabolites of arachidonic acid and the control of renovascular tone

20-HETE–NO interaction

CYP450 metabolites of arachidonic acid and regulation of sodium transport

CYP450 metabolites of arachidonic acid and hypertension

Notes

References


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