Nephrol Dial Transplant (2001) 16: 2143-2145
© 2001 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Neoangiogenesis in the peritoneal membrane: does it play a role in ultrafiltration failure?
Renal Unit, University Hospital, Gent, Belgium
Keywords: neoangiogenesis; peritoneal membrane function; ultrafiltration failure
Introduction
Long-term preservation of peritoneal membrane function is a prerequisite for successful peritoneal dialysis (PD). The development of ultrafiltration failure (UFF) is the most important cause of technique failure next to recurrent peritonitis [1]. Its significance is likely to increase as the reduction in peritonitis rates makes PD a more viable option for a larger number of patients. The present overview briefly discusses the alterations in peritoneal membrane function that underlie loss of ultrafiltration capacity. In addition, the structural changes observed in the peritoneum of long-term PD patients will be addressed. Finally, an attempt will be made to provide a link between the functional and morphological alterations.
Functional alterations
Evaluation of peritoneal transport characteristics in patients with UFF reveals distinct mechanisms of impaired ultrafiltration capacity. The presence of low small solute transport rates is probably very rare and points to a major decrease in membrane surface area, usually
Structural alterations
Functionstructure correlation
Conclusion
Notes
References
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